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KMID : 0359819950240070800
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Journal of Korean Neurosurgical Society
1995 Volume.24 No. 7 p.800 ~ p.813
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Intracranial Chordomas: Clinical Review and Therapeutic Outcome
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김충현
하영일/송관영/한윤경
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Abstract
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Chordomas are uncommon tumors arising from the embryonic remnants of the fetal notochord. The spheno-occipital region accounts for 36 percent of chordomas. The authors are presenting four cases of intracranial chordomas with clinical
manifestation
was
analyzed. All patients were men and their mean age was 37 years old. The presenting complaints ere diplopia in 2 patients and decreased visual acuity in the other two. Radiologic studies demonstrated extensive bony destruction of the skull base
and
soft
mass with punctate calcification in all 4 cases. Treatment consisted of subtotal removal of tumor and subsequent radiotherapy. Histopathologically. three of the four patients had typical chordomas and the remaining case was confirmed as chondroid
chordoma. The three typical chordomas recurred after initial treatment. 2 of these three were reoperated but died in the 10 months 33 months. respectively after initial diagnosis. The patient with chondroid chordoma remained well for 46 months
after
initial treatment without significant neurological deficits.
In conclusion. therapeutic outcome of intracranial chordomas are grim because of their aggressive that frequent recurrence and inability to remove tumors completely. With the exception. chondroid chordoma has good prognosis and long term
survival.
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